Hualien Tzu Chi Hospital is located in a high-risk disaster-prone region and has long faced challenges including earthquakes, typhoons, transportation disruptions, and cultural diversity. Drawing on extensive frontline disaster response experience, the Department of Nursing has systematically transformed operational pain points encountered during multiple disaster events into institutionalized practices, progressively establishing a nursing-led disaster governance model. This initiative integrates disaster education, workforce development, technological innovation, and humanistic care to form a governance system characterized by structural completeness, traceable processes, and verifiable outcomes. Through a three-tier disaster education framework, a three-stage nursing disaster workforce pool, and the Nursing Resilience Taskforce formally embedded within the Hospital Incident Command System (HICS), nursing professionals are empowered not only to respond rapidly on-site but also to play a critical role in organizational decision-making. The model has demonstrated outcomes surpassing both national and international benchmarks and exhibits strong potential for replication and national-level dissemination.